[HTML][HTML] Pain regulation by gut microbiota: molecular mechanisms and therapeutic potential

R Guo, LH Chen, C Xing, T Liu - British journal of anaesthesia, 2019 - Elsevier
microbiota regulates pain in the peripheral and central nervous system, and targeting gut
microbiota by … long-lasting enhancement of visceral pain in adult mice via disturbance of the gut …

[HTML][HTML] Inflammasome signaling regulates the microbial–neuroimmune axis and visceral pain in mice

M Aguilera, V Rossini, A Hickey, D Simnica… - International journal of …, 2021 - mdpi.com
… for the inflammasome in microbiota-neuroimmune interactions and visceral pain responses.
… in neuro-immune responses and visceral pain attenuation in WT but not in Casp1 KO mice. …

Gut microbiota influences neuropathic pain through modulating proinflammatory and anti-inflammatory T cells

W Ding, Z You, Q Chen, L Yang, J Doheny… - Anesthesia & …, 2021 - journals.lww.com
… , visceral pain, and fibromyalgia. We hypothesize that gut microbiota influences the development
of neuropathic pain … hypothesis in a mouse model of CCI, using neuropathic pain as the …

Gut microbiota modulates visceral sensitivity through calcitonin gene-related peptide (CGRP) production

J Pujo, G De Palma, J Lu, HJ Galipeau, MG Surette… - Gut …, 2023 - Taylor & Francis
… We investigated pain responses in germ-free and conventionally raised mice of both sexes,
… regulation of visceral pain demonstrating that visceral sensitivity is modulated both by the …

[HTML][HTML] Animal models of visceral pain and the role of the microbiome

C West, KAMV Neufeld - Neurobiology of Pain, 2021 - Elsevier
… to the intestinal microbiome, … visceral pain in rodent models, then go on to discuss studies
that directly manipulate the intestinal microbiota, using germ-free mice, antibiotic treated mice, …

[HTML][HTML] Colitis-induced microbial perturbation promotes postinflammatory visceral hypersensitivity

N Esquerre, L Basso, M Defaye, FA Vicentini… - Cellular and molecular …, 2020 - Elsevier
… of visceral, but not somatic, pain in a mouse model of … of chronic visceral pain, in which
animals display increased visceralmicrobiome was necessary for the expression of visceral

[HTML][HTML] Gut microbiota alter visceral pain sensation and inflammation via modulation of synthesis of resolvin D1 in colonic tuft cells

G Grabauskas, J Gao, X Wu, SY Zhou… - …, 2022 - ncbi.nlm.nih.gov
… gut bacteria in regulating RvD1 synthesis, we colonized germ-free mice with different strains
visceral hypersensitivity in WT mice suggesting that gut microbiota may regulate visceral

[HTML][HTML] Visceral sensitivity modulation by faecal microbiota transplantation: the active role of gut bacteria in pain persistence

E Lucarini, V Di Pilato, C Parisio, L Micheli, A Toti… - Pain, 2022 - journals.lww.com
… The present work aimed to evaluate the power of gut microbiota as a visceral pain … in
reversing postinflammatory visceral pain persistence. Colitis was induced in mice by intrarectally …

[HTML][HTML] Gut microbiota depletion by antibiotics ameliorates somatic neuropathic pain induced by nerve injury, chemotherapy, and diabetes in mice

P Ma, R Mo, H Liao, C Qiu, G Wu, C Yang… - Journal of …, 2022 - Springer
… Resident in the gut, gut microbiota is able to regulate local mucosal … like visceral pain
sensations [4]. What’s more, evidence starts to uncover the capacity of gut microbiota in regulating

Microbiota: a novel regulator of pain

M Defaye, S Gervason, C Altier, JY Berthon… - Journal of neural …, 2020 - Springer
… to determine the involvement of the intestinal microbiota in visceral pain. The application of
a … in the development of visceral pain. Several studies have shown that GF mice (raised in a …